Accelerating Drug Discovery

Safety & Efficacy data for chemicals & novel therapeutics

Human-on-Chip®

Functional, interconnected, multi-organ in vitro platform providing unprecedented visibility into how the human body will respond to chemicals & novel therapeutics.

  • Human, safety & efficacy data
  • Unprecedented preclinical insight
  • Reducing the need for animal testing

This breakthrough, platform technology enables investigation into every human disease from ALS, Alzheimer's, and Cancer to rare diseases with no existing treatment.

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Human Models for Human Diseases

Unprecedented insight into how the human body will respond to chemicals & novel therapeutics

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Human, multi-organ in vitro platform

Current systems expand up to 5-organ compartments that are easily interchanged to investigate specific disease types.

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One Platform for Drug Discovery

Physiologically realistic models accurately predict patient responses

Absorption, Distribution, Metabolism, Excretion

Understand the rate that a chemical is absorbed and distributed, the rate and pathways of drug metabolism and excretion, and the plasma concentration of a drug over time.

Disease Modeling

Reproduce the functional aspects of specific disease states gaining visibility into how specific organ tissues are damaged and recover in response to various treatments.

Drug Safety & Toxicology, simultaneously

Determine efficacy and off-target toxicity for both parent compounds and there often more active metabolites. Enables determination of therapeutic index.

Drug-Drug Interactions

Understand the effects of both single drug treatments AND drug-drug combinations - all in the same system.

Select Organ Modules

Easily interchange an ever-growing list of available organs depending on your application. Cells derived from patient samples & iPSC. 

Primary Organs

  • Heart

    Both contractile force and electrical activity measured in real-time

  • Liver

    Liver

    Functional liver metabolizes drugs as expected in the human body

  • Brain

    Neurons

    Study neuronal diseases including Alzheimers

  • Skeletal

    Skeletal Muscle

    Study a wide range of diseases such as ALS and Parkinson's with a functional neuromuscular junction model

  • Kidneys

    Kidney Renal Proximal Tubule (RPT)

    Determine the reabsorption, secretion profile, and kidney safety of your compound using our Kidney RPT model

Barrier Tissues

  • Skin

    Skin

    Determine the transdermal diffusion of novel compounds applied topically and monitor the effects of the absorbed drugs on organ physiology

  • BBB

    Blood-Brain Barrier (CNS)

    Investigate the transport rates, mechanisms, and barrier effects as novel chemicals and biologics enter the central nervous system

  • Immune System

    Monocytes can be added to the recirculating medium in our multi-organ systems characterized for activation markers and differential cytokine release profiles

  • Gastointestinal

    GI Tract

    Reproduce absorption and first-pass metabolism with our GI-tract model

About the Technology

Select Research Institutes & Commercial Partners

We are funded and collaborate with the best.  A select list as follows:

Awards

We are proud to enable treatment development for every disease while eliminating the need for animal testing.  Here is a select list of awards we've picked up so far.  

2016 - Cade Prize Finalist
2018 - GrowFL Top 50 Company to Watch
2015 - Lush Prize Winner
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Schedule a webinar with our team of experts to find out how we can accelerate your development.

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Hesperos, Inc.
12501 Research Parway, Suite 100
Orlando, Florida 32826

(407) 900-5915
info@hesperosinc.com

Latest News

Changing the Industry: Thrive Global’s Interview with Dr. Michael Shuler

ALS Pathology Investigated by Researchers from UCF & Hesperos Utilizing a Human-on-a-Chip model.

Dr. James J. Hickman elected as Fellow of the National Acadamy of Inventors!

Dr. Hickman’s Presentation at AAPS about Human-On-A-Chip® technology

Future Tech Podcast Interview with James Hickman, PhD, Human-Based Models for Drug Testing